Sewickley is a borough in Allegheny County, Pennsylvania, 12 miles (19 km) west northwest of Pittsburgh along the Ohio River. It is a residential suburb of Pittsburgh.

The population was 3,827 at the 2010 census. The Sewickley Bridge crosses the Ohio River at Sewickley.

Sewickley is thought to be a Native American word meaning "sweet water." Historians dispute if Native Americans were referring to the Ohio River as the "sweet water" or instead to the syrup derived from a local abundance of maple trees.

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